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Integrating multi-omics data, a pathway analysis, and computational modeling may offer powerful tools to investigate metabolic reprogramming in ECs during aging and atherosclerosis, as exemplified by Kalucka et al.s single-cell RNA-sequencing (scRNA-Seq) atlas of 11 mouse tissues, which revealed 78 EC subclusters and highlighted tissue origin as the primary determinant of EC heterogeneity, including tissue-specific metabolic profiles [234]

Sensors 23 (19), 8172 (2023)

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In autoimmune hepatitis (AIH)-associated inflammation, the polarization of hepatic macrophages, including Kupffer cells and monocyte-derived macrophages, is likewise regulated by arginine metabolism

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For example, in some microorganisms, glycine can be produced through the conversion of other amino acids or through specific metabolic by-passes