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In particular, a subset of inflammatory immune cells called Th17 cells are principally responsible for driving inflammation in Crohns disease, while Th2 cells drive inflammation in ulcerative colitis

Glutathione has proven skin-brightening properties and helps reduce oxidative damage

10.3233/CH-189012 Clin

Targeted therapy against ROS A synthetic antioxidant regimen has been established with four main approaches: lipid-lowering, blood pressure-lowering, thiol supplementation, and enzyme replacement Statins block the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, reduce Rac1 membrane translocation, thereby lowering ROS derived from NOX, while stabilizing eNOS mRNA, increasing NO bioavailability, and inhibiting various adhesion molecules, achieving a dual suppression of oxidative stress and inflammation [486]

Additionally, crocodilian oil attenuated DNA damage and upregulated the expression of cell-cycle regulators, D2 and E2, indicating a role in modulating immune responses (30)

10.1016/j.gene.2022.146460 190 ShenL.-D.QiW.-H.BaiJ.-J.ZuoC.-Y.BaiD.-L.GaoW.-D.et al (2021)