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However, these treatments are costly, leading to equity issues with access to therapy

In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

4- The analogs of CNTF and ADAM10 are available for clinical use as vitamin A supplements can upregulate ADAM10 and have been extensively studied in SSD and ASD

Carrington, J.C

doi: 10.1007/s00059-011-3429-4 107 VasanRS

Fisher B