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Membantu proses kematian sel yang normal (apoptosis)

Cancer Cell 5 , 221230 (2004)

21 Fletcher-SandersjA.ThelinE

The SOD-catalyzed dismutation reaction is highly efficient, which occurs at the almost diffusion-limited rate of 2 10 9 M 1 S 1

Here, elevated NO production as a result of increased activation of NOXs, in particular NOX4 leads to the stabilisation of HIF-1 and thus promotion of endothelial cell (EC) survival, migration, differentiation, and therefore neovascularisation 64,106,107,108