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In earlier trials, about 70% of patients experienced at least one mild adverse effect similar to those seen with other vaccines, including injection site pain, rash, headaches, muscle soreness, and fevers

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Evidence Service to support the COVID-19 response April 14, 2020 Dr Oliver Van Hecke, Dr Joseph Lee On behalf of the Oxford COVID-19 Evidence Service Team Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford Correspondence to [email protected]

doi: 10.2105/AJPH.2012.300926 30

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase