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In our previous attempts with Rosetta-based approaches, designing large structured macrocycles posed significant challenges and required additional disulfide crosslinks to stabilize them 18

doi: 10.3389/fpsyt.2023.1142608 Received 11 January 2023 Accepted 26 January 2023 Published 09 February 2023 Volume 14 - 2023 Edited by iek Hocaolu, Recep Tayyip Erdoan University, Trkiye Reviewed by Mehmet Hamdi rm, Elaz Eitim Ve Aratrma Hastanesi, Trkiye

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