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Clinical Implications and Translational Pathways in Intracranial Hypertension Management Intracranial hypertension is a multifactorial phenomenon that will require multi-pronged treatment approaches consisting of advanced diagnostics, personalized therapies, and interdisciplinary collaboration

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b Relative endogenous H2O2 levels and c cellular toxicity in CHO cells stably expressing myc-parkin ( PRKN+ ) or myccontrol vector ( PRKN- ) with or without exposure to 2 mM H2O2, 2 mM BSO, or 20 mM N-acetyl cysteine (NAC), as indicated