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Folic acid corrects the hematologic manifestations of pernicious anemia, while the neurologic complications progress, potentially causing irreversible central nervous system effects

455 Future research should elucidate how aberrant sensory afferent activity interacts with maladaptive CNS plasticity to initiate and sustain neuropathic pain

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Zn deficiency can result in growth stunting, affecting the skin, gastrointestinal tissues, the immune system, the skeletal system, and the reproductive systems most severely (20)