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And if we globally suppress it with powerful drugs, were less able to fight these pathogens and threats

(1997) Nature 390, 465-71

4-HNE is a byproduct of lipid peroxidation that can alter protein functions by forming 4-HNE-protein adducts, induce DNA damage, and act as a signaling inducer ( via apoptosis caused by accumulating 4-HNE

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In addition, superoxide anions will react with nitric oxide (NO) to produce peroxynitrite (ONOO ), which causes nitrosative stress

The project was headed up Nancy Thornberry, a biologist, and Ann Weber, a chemist (figure 34)