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This review summarizes GBM pathogenesis and ferroptosis mechanisms, then focuses on ferroptosis-targeted GBM therapy through target sites and pharmacological agents

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Genetic predisposition First-degree relatives have a higher likelihood of developing IC/PBS compared to the general population, indicating that the occurrence of the disease may have a zygotic link, whether monozygotic (identical twins) or dizygotic (fraternal twins) (Warren et al., 2004)

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Hypertension, ischemic heart disease, patients with atherosclerosis and coronary artery disease, diabetes, chronic lung diseases, smoking and obesity are associated with low baseline GSH levels and reduced GSH/oxidized glutathione (GSSG) ratios (Khanfar and Al Qaroot, 2020

A.et al (2017)