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Early exposure to stress and trauma of genetically susceptible individuals might influence the critical period of brain development and modify key neural and inter-neural pathways over different timepoints (prenatal life, perinatal life, adolescence, and adulthood) [19], pushing towards an emotional and psychotic reactivity to future life stress (stress sensitization) [20, 21]

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After inspection of the apo-OsDHAR structure, we predicted that the highly conserved Cys20 residue acts as the catalytic nucleophile and found that this residue is located at the cleft between the N- and C-terminal subdomains

Specific objectives Primary objectives Measure whether daily maternal administration of 50 g vitamin B 12 from early pregnancy until 6 months postpartum improves cognitive, language and motor scores of the Bayley-III measured at 6 and 12 months of age

These include the mediation of epigenetic changes such as DNA methylation and histone modifications [214, 215], as well as interference with the balance of intestinal microbiota influencing host metabolism and immune status [216, 217]