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Evolution of Drug Development and Regulatory Affairs: The Demonstrated Power of Artificial Intelligence

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Proliferating megakaryocytes secrete VEGF along with hematopoietic cytokines, resulting in autocrine stimulation of their growth, increased endothelial proliferation [25]

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2.3.2 Takeda G protein-coupled Receptor 5: a complex regulator of inflammatory responses and cell function Distinct from the nuclear receptor FXR discussed previously, Takeda G protein-coupled Receptor 5 (TGR5, or GPBAR1) serves as a primary cell surface sensor for secondary bile acids (SBAs), particularly lithocholic acid (LCA) and deoxycholic acid (DCA), which are generated through gut microbial metabolism ( Activation of TGR5 classically triggers Gs-cAMP-PKA signaling, which often exerts anti-inflammatory effects