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Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis

583 In addition to the traditionally recognized loss of dopaminergic neurons in the substantia nigra and intracellular alpha-synuclein (-syn) deposition, the brains of PD patients exhibit iron deposition, heightened oxidative stress, and lipid peroxidation damage

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[60] supported this hypothesis by showing that lactate stimulates PASMC proliferation in a concentration-dependent manner

Tissues from mice used in Fig

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