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Fecal MPO, a protein which is released from azurophilic granules upon neutrophil activation, predicts 60-day survival in patients with AH (high MPO level HR: 2.84, logrank: P=0.035)

MaranoMAnziniGSaltarocchiLRicciutiRCaponeFTanHet al

The small molecule drug discovery process begins with identifying a biological target and progresses through hit identification, hit-to-lead evolution, and lead optimisation before compounds enter preclinical in vivo and clinical testing

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doi: 10.1128/AEM.71.12.8442-8450.2005 42 KeyerK.ImlayJ