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activity can less readily be determined in fibroblasts, leukocytes, and other tissue extracts

doi: 10.1001/jama.2015.16535 130 KundakovicMRocksD

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Upon Wnt ligand binding to FZD and LRP5/6 at the cell surface, Dishevelled (Dsh/DVL) proteins are activated and inhibit the destruction complex

Controlled trials have shown that short-term growth velocity increases, and results are consistent with an approximate increase of 4 to 6 cm over predicted height following approximately 5 years of treatment, with a dose-dependent effect and better outcomes in children treated earlier and longer during a prepubertal period

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