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5.2 Neurotransmitter and neuroendocrine regulation Periodontitis-related oral dysbiosis can disrupt the gut microbiota via multiple pathways, contributing to depression through neurotransmitter and neuroendocrine mechanisms

(2021) used CRISPR/Cas9 to establish transgenic zebrafish lines that express mutated NF1 , Rb1 or TP53 under GFAP promoter and showed that various combinations of NF1 , TP53 , and/or Rb1 mutations can induce gliomas of different grades and phenotypes (108)