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A major emerging theme in understanding the diverse actions attributed to these proteins involves their ability to adopt multiple states dependent on the nature of the bound ligand

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Biochim Biophys Acta 1830:32173266 Dhankher OP, Li Y, Rosen BP, Shi J, Salt D, Senecoff JF et al (2002) Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and -glutamylcysteine synthetase expression

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The large increase in new chronic infections apparent (Figure 1A and B) is due to reinfections among recently cured PWID