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mTOR is a serine/threonine kinase with two complexes, mTORC1 and mTORC2 [63]

Figure 5 2.2.4 GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4) The GCH1/BH4 pathway is an intracellular enzymatic pathway involved in various crucial cellular metabolic processes (81, 82)

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To meet the diagnostic criteria for cEDS, a person must meet: Major criterion 1 AND major criterion 2 OR Major criterion 1 AND three or more minor criteria Major Criteria Skin hyperextensibility and atrophic scarring Generalized joint hypermobility Minor Criteria Easy bruising Soft, doughy skin Skin fragility (or traumatic splitting) Molluscoid pseudotumors Subcutaneous spheroids Hernia (or history thereof) Epicanthal folds Complications of joint hypermobility (e.g., sprains, dislocations/subluxations, pain, flexible flatfoot) Family history of a first-degree relative who meets clinical criteria Genetic testing is used to see if a person has a genetic variant that causes vEDS

Several studies underscore that MSC-EVs are generally well-tolerated and exhibit lower immunogenicity compared to their parent cells, enabling safer systemic administration with minimal adverse immune responses [142-144]

The role of non-genetic therapies to reduce the incidence of sickle cell crisis: a systematic review