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Too much uric acid in the blood, however, can end up causing pain, swelling, or inflammation

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Perfusion and in vitro clotting studies first demonstrated that NETs recruit platelets and red blood cells, promote fibrin deposition, and create a pro-thrombotic scaffold whose enzymatic and electrostatic properties facilitate thrombus formation

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Circulatory shock with fever, severe hypotension, and confusion requiring intravenous fluid resuscitation and vasopressors has occurred within minutes to hours of re-challenge with sulfamethoxazole and trimethoprim products, including sulfamethoxazole and trimethoprim, in patients with history of recent (days to weeks) exposure to sulfamethoxazole and trimethoprim