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SOD1 WT misfolding has been shown to occur in the spinal cord of sporadic (sALS) and non-SOD1 fALS patients 13,14,18,19,20,21,22,23 , and it was proposed that misfolded SOD1 WT and mutant proteins (SOD1 MUT ) share a common pathogenic pathway in ALS 18,23,24

T., Hibino, T., Takabe, T

Gene therapy and emerging approaches Emerging gene therapy approaches further expand the therapeutic landscape

DNA damage, defective DNA repair, and neurodegeneration in amyotrophic lateral sclerosis

K., Gupta, R

4 First-generation antihistamines are less favored because they cause greater reduction in milk supply and maternal and infant sedation