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Subsequent cleavage of this fragment by -secretase produced A40 and A42 peptides, both of which were central to the aggregation of neuritic plaques, and BACE1 activity was recognized as an early biomarker of AD (Nicsanu et al., 2022)

However, despite these differences, they converge on a limited set of cellular stress pathways that compromise epithelial integrity and mucosal barrier function