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Studies have shown that vitamin D can inhibit TGF--Smad signaling pathway (156, 158160) through the specific process of 1,25(OH) 2 D 3 binding complex with VDR, which directly interacts with SMAD3 to reduce the binding of SMAD3 to DNA, and ultimately inhibit TGF--Smad signal transduction (161, 162)

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Trends Pharmacol Sci (2012) 33(12):65668.10.1016/j.tips.2012.09.007 65 TewKDTownsendDM

ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis

Furthermore, in the immune microenvironment of SS, SGECs exhibit damaged DNAse1, leading to abnormal accumulation of cytoplasmic DNA and excessive activation of AIM2

Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, and Stampfer MJ (1998)