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Lastly, through a genome-wide CRISPR loss-of-function screen, we confirmed that the effects of LCS3 are related to antioxidant response and found that inactivation of NADPH quinone oxidoreductase 1 (NQO1) impairs ROS production and confers resistance to LCS3

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An imbalance between bioactivation and bioinactivation leading to toxicity may however be created by taking a drug overdose

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J Neurosci Res 66: 9981002

This simple chart makes it clear that your prioritiesbe it speed, color, or costwill steer you toward one or the other