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doi: 10.1056/NEJMoa1803917

Similar content being viewed by others Introduction Diabetes stands as a formidable global public health challenge, casting a substantial burden on both public health and socio-economic development worldwide

dataset showed that GPX4 demonstrated the highest variability (standard deviation of log2 fold changes = 0.39), followed by EIF3B (0.26) and ST3GAL1 (0.24)

Inhibition of Glutamate-to-Glutathione flux promotes tumor antigen presentation in colorectal Cancer cells

It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation

Such heterogeneity complicates the development of universally effective therapies and underscores the need for personalized approaches, which currently face limitations due to an incomplete understanding of these individual determinants (164)