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In the present study, we detected significant upregulation of pro-inflammatory factors ( IL1B , TNF , IFNG , NOS2 , CD86 , IL6 and IL12 ) along with downregulation of anti-inflammatory mediators ( IL4 , IL10 , MRC1 and ARG1 ) in the livers of iron-deficient suckling piglets, confirming that ID skews hepatic immunity toward a pro-inflammatory state and causes liver injury

518 Notably, a CHOP element, coupled with the C/EBP domain, was found in the gene promoter regions

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Mol Med (1995) 1(3):25466