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Thus, in the future, breakdown of the vicious cycle through modulating mitochondrial function is a potential therapeutic strategy in the management of sepsis (Fig

TJ complexes are primarily composed of transmembrane proteins including occludins, junctional adhesion molecules, and claudin family members that function collectively to form pores with selective permeability to ions and molecules (Brenchley and Douek 2012

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And the dose-dependent effects were clear: 4 mg, 8 mg, and 12 mg doses all produced escalating weight loss, with the highest dose delivering the most dramatic results

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