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To alleviate chronic inflammation, overcome insulin resistance (IR) and to prevent -cell apoptosis, stem cells or stem cell derivatives such as insulin-producing cells (IPCs) and exosomes have been suggested (8689)

In adults, it is primarily found in neurons in the cortex, hypothalamus, and hippocampus, as well as in epithelial cells of the choroidal plexus and ependymal and endothelial cells of blood vessels [45, 67, 68]

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Second, the peptides direct interaction with chromatin-associated proteins may influence the transcriptional regulation of antioxidant genes independently of melatonin signaling

10.1074/jbc.M112.344093 14 BouchardM