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Studies have shown that Mn dysregulated mitochondrial bioenergetics in astrocytes, resulting in the release of proinflammatory cytokines and adjacent neuronal injury (Sarkar et al., 2018)

However, most wound healing research uses native IGF-1, not LR3 specifically

Robinson, D.S., Ying, S., Bentley, A.M., Meng, Q., North, J., Durham, S.R., Kay, A.B., Hamid, Q., Relationship among numbers of bronchjoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacoline responsiveness in atopic asthma, J