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Although this PDT/PARPi combination demonstrates impressive synergistic antitumor and immunostimulatory effects, a more systematic evaluation of its therapeutic window, optimal light dosing, and inclusion of rigorous control groups is needed to fully substantiate its clinical translatability

It is also recognized that mitochondrial abnormalities not only act by altering metabolism but, through effects on mitochondrial dynamics, can regulate numerous cellular processes including intracellular calcium handling, cell proliferation, apoptosis and quality control

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* P 1.30, corresponding to FDR 1.30, corresponding to FDR 1.30, corresponding to FDR 1500 mm 3 ) for MC38-OVA tumors

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Anabolic steroids (exogenous [from outside the body] testosterone and testosterone-like drugs) used by some athletes and body builders suppress hormonal signals from the brain that are needed to stimulate normal sperm production and maturation