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The presence of vWF and platelets in areas of positive H3Cit staining in DVT was observed by assessing venous thromboembolism in surgical or autopsy specimens, demonstrating not only that histone citrullination occurs in DVT, but also that NETs, vWF, and platelets influence the formation and stability of DVT (83)

Rossing K, Christensen PK, Hovind P, Tarnow L, Rossing P, Parving HH

Hypotension, hypocalcemia, nausea, vomiting, and sneezing are the most common side effects of amifostine therapy [151], and switching to the subcutaneous route of amifostine at a 1000 mg dose is better tolerated with minor side effects in patients who are poorly tolerated with intravenous administration [152]

A bone marrow aspirate (if done) would reveal erythroid hypoplasia with increased bone marrow iron (due to hepcidin-mediated sequestration and suppression of bone marrow erythropoiesis)

Zinc itself plays a real role in wound repair because it is a cofactor for the enzymes involved in collagen building, calming inflammation, and helping new skin cells cover a wound

However, the presence of metal ions from MOFs may raise concerns about biological safety