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The shift increases alcohol breakdown but also generates large amounts of reactive oxygen species (ROS), contributing to tissue damage during chronic drinking

ROS degrade polyunsaturated lipids, generating MDA (Pryor and Stanley 1975)

However, neither our AP-day nor AP-life drug exposure measures contributed to the phase-related reduction in dACC glutamate in our mediation analysis (Fig

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vivo J Leukoc Biol