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(3) Clinical Validation: Large-scale, well-designed clinical trials are urgently needed to evaluate the safety and efficacy of ferroptosis-targeting strategies (e.g., deferiprone, novel inhibitors) in COPD patients, ideally using biomarker-driven patient selection (e.g., based on MDA, 4-HNE, or GPX4 activity levels)

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We investigated the impact of pyramidal tract lesions, including the posterior corona radiata and the primary motor cortex, which are not evaluated by conventional imaging parameters, on clinical outcome