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Abbreviations APAP : Acetaminophen GJ : Gap-junction NAC : N-acetylcysteine GSH : Glutathione NAPQI : N-acetyl-p-benzoquinone imine ROS : Reactive oxygen species Nrf2 : Nuclear factor E2-related factor 2 Cx32 : Connexin 32 TTSP : Type II transmembrane serine protease HGF : Hepatocyte growth factor References Chiew AL, Isbister GK

Scand J Clin Lab Invest 76:234239 Watowich SS (2011) The erythropoietin receptor: molecular structure and hematopoietic signaling pathways

Using the ratiometric redox sensitive GFP (roGFP) construct, we show that both moderate raise of ambient temperature (27-29C) and more intense high stress (37C) lead to oxidation of the roGFP both in the cytosol and the nuclear compartment, but with different kinetics depending on the heat treatment

In toxicity studies, exposure to the acyl glucuronide metabolite M8 at the no-observed adverse-effect level was similar to or higher than human exposure at the highest phase 3 dose (200 mg twice daily) although exposure to the minor circulating metabolite M9 was lower

BMC Cancer (2021) 21:943