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These elevated ROS levels damage oxidative DNA, prominently affecting the TP53 tumor suppressor gene

High-molecular-weight polysaccharides will be eluted first with the mobile phase, while the low-molecular-weight polysaccharides will diffuse into the pores of the gel and elute later (48)

10.3390/pharmaceutics15030879 131 HerdianaY.WathoniN.ShamsuddinS.MuchtaridiM

Pulmonary sarcoid-like granulomatosis induced by nivolumab

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Paradoxically, the resultant abnormal vasculature exacerbates hypoxic conditions and creates a vicious cycle, wherein the progressively abnormal TME continues to foster angiogenesis and hypoxia in tumors