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Development of wheat genotypes expressing a glutamine-specific endoprotease from barley and a prolyl endopeptidase from Flavobacterium meningosepticum or Pyrococcus furiosus as a potential remedy to celiac disease

The ferroptosis agonist, erastin, further increased the levels of NGAL and KIM-1, while the ferroptosis inhibitor, ferrostatin-1, significantly downregulated the levels of NGAL and KIM-1 (Fig

It was already found that effective inhibitors for MRP and Pgp are different, though some Pgp modifiers can in part inhibit MRP functional activity

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In GCLC-deficient T cells, excessive ROS accumulation due to impaired GSH biosynthesis inhibits calcineurin function, thus suppressing NFAT activation and impairing T cell metabolic reprogramming