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Together, these results demonstrate that both pharmacological and genetic DHODH inhibition effectively impair A431 tumor growth in vivo, with PTC299 exhibiting the strongest antitumor activity

Adolescents whose brains are still developing are more vulnerable than adults to ketamine-induced neuronal apoptosis and cognitive deficits (Yin et al., 2022)

Their structural components include the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), mitochondrial matrix, and intermembrane space (IMS) (Wang et al., 2024)

Strikingly, the secondary addition is considerably slower than the primary one, which allows for the controlled preparation of mono-, multi-functionalized proteins or disulfide-bridged conjugates via adjusting the ratio of reagents and reaction conditions

Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy

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