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J Pharmacol Exp Ther 261:910917

Antibiotics can also alter the diversity of the composition of the gut microbiota (Dethlefsen and Relman, 2011) with potential implications for neurochemistry and behavior (Bercik and Collins, Salmonella enteritidis showed increased intestinal permeability as measured by 24 h urinary CrEDTA compared to the uninfected control group (van Ampting et al., 2010)

The design of an ADC is therefore a delicate balancing act: the antibody, linker, and payload must work in concert to achieve potent, tumor-specific activity without unacceptable toxicity

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The typical components include: Vitamin B12 (cobalamin): An essential water-soluble vitamin crucial for red blood cell formation, neurological function, and DNA synthesis