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ROS, like H 2 O 2 and superoxide, act as activators or inhibitors of NF-B, while NF-B has pro- or antioxidant effects depending on oxidative stress levels

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Certain repopulated primary hepatocytes in the proximity of bile ducts reconstructed by liver ductal organoids expressed MRP2, one of the bile acid transporters, and ZO-1 in membranous area

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By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

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