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However, glucose and/or adenosine triphosphate (ATP) deprivation, oxidative stress and compromised mitochondrial function may result in the accumulation of cytotoxic mediators and energy depletion

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Furthermore, some disturbance in these organelles activates signaling pathways that alter cardiac ion channels function or expression, involved in the generation of an action potential that promotes arrhythmogenesis (Tse et al., 2016)

444 In cases of extensive necrosis involving the retrocolic and/or mesenteric spaces where complete necrosectomy cannot be achieved in a single procedure, open packing or staged laparotomy may be employed as a damage control strategy

10.1039/C6FO00958A 56

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