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PNI is a pathological process that eventually leads to cancer cells invading peripheral nerves

In response to genotoxic chemotherapy exposure, TNBC cells adaptively upregulate pyrimidine synthesis to increase the production of nucleotides necessary for DNA repair, whereas using leflunomide, a clinically approved inhibitor of de novo pyrimidine synthesis for the management of rheumatoid arthritis, sensitizes TNBC cells to chemotherapy and causes significant tumor regression when used in combination with doxorubicin 115

Most recently, Zhukauskas R et al

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How Glutathione Supports Healthy Aging and Cellular Longevity Aging happens at the cellular level and so does protection