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This is consistent with the previous findings that hypoxia-response genes were upregulated in the islets of diabetic, but not prediabetic, db/db mice in an inverse relationship with unfolded protein response gene expression 28,33

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Schizophyllan helps the tumorbearing host's cellular immunity by acting as a macrophage activator, a Tcell adjuvant, and a promoter of cytokine production (Stoica et al