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Masarova L, Verstovsek S, Patel KP, Newberry KJ, Cortes JE, Borthakur G , Konopleva M, Estrov Z, Kantarjian HM

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Key Takeaway Complete review of the BPC-157 safety profile including side effects, contraindications, drug interactions, and what the research tells us about this peptide's tolerability

The thiomethyl shunt involves the activity of CCBL to cleave cysteine S-conjugates, and subsequent methylation with an active form of methionine to produce thiomethyl metabolites ( 9, 21 ), meaning that APAP-SG and NAC-APAP were probably biotransformed to APAP-cysteine beforehand