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Considering a three-dimensional structural model for a complex of the human HGF-NK2 segment sandwiched by c-met receptor molecules (see supplementary Figure 3, re-produced from PDB ID 7MO7 67 , it is hypothesized that the disulfide bonds, notably Cys149-Cys189 and Cys177-Cys201 localized internally just behind Y198, are the targets of LASSS

Future studies are needed to reconcile the underlying differences between tumor tissue and basal PTC cell line GPX4 expression levels and in vitro responses to pharmacologic inhibition of GPX4 within an emulated 3D thyroid tumor microenvironment in vitro and in vivo

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