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Chemokine (C-X-C motif) receptor 4 (CXCR4) expression increases during progression of PCa and is associated with metastatic disease and poor survival [50, 51] CXCR4 selectively binds to stromal cell-derived factor 1 (SDF-1)/ CXCL12, also overexpressed in PC metastatic tissue compared to normal tissues [52]

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Studies have revealed abnormal levels of lipids, amino acids, carbohydrates, and nucleotide metabolism in COPD patients, playing crucial roles in disease progression (Xu et al

While this study found an increase in androgen receptor expression and some other shenanigans, the other study (by the same research group, mind you) assessed many different hormones and found an increase in one of the insulin-like growth factors known as IGFBP-3