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Calverley PM, Page C, Dal Negro RW, Fontana G, Cazzola M, Cicero AF, Pozzi E, Wedzicha JA

This surfactant contains most of surfactant lipids plus the hydrophobic proteins SP-B and SP-C, which are responsible for the spreading of the lipid/protein complexes to form layers at the air-exposed surface of the alveolar epithelium

aeruginosa has many systems dedicated to the regulation of oxidative and heavy metal stress (i.e., a catalase, siderophores, efflux pumps and metal reduction), these systems may compensate for the lack of PmtA in the pmtA mutant, resulting in no defect being observed under the assayed growth conditions

Through network pharmacology analysis, Guo et al (115) discovered that regulating the AGE-RAGE signaling cascade and the gene expression of its downstream effector molecules is the key mechanism through which bioactive ingredients, such as AS-IV, in Bu Yang Huan Wu Decoction exert anti-PF effects

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