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Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion

Give it three months at minimum before you evaluate results, reminding yourself this is a long-term optimization protocol and NOT a quick fix

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Previous research has generally held that SHBG does not cross the BBB [184]

Additional contributing factors include increased expression of insulin-like growth factor 1 (IGF1) receptors, IGF1-binding protein (which protects IGF1 from proteolysis) in Purkinje cells [8], as well as upregulated mRNA expression of GLUT1 and GLUT3 [80]