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At each post-operative time point of interest, mice were then euthanized with intraperitoneal injection of pentobarbital

Simultaneously, the opening of the mitochondrial permeabilization transition pore (mPTP) releases pro-apoptotic factors (such as Cyt-c), triggering endothelial cell death

10.1002/jev2.12076 J

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This process can, in turn, lead to an escalation in the risk of drug resistance and relapse