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Romao, who summarized the recent research with oral SOD-gliadin (see #4 in Sources below), concludes that supplemental SOD-gliadin may represent a meaningful quality-of-life improvement, but emphasizes that most studies on the SOD-gliadin formulation indicate that supplementation presents auxiliary effects rather than curative properties and recommends more large-scale experimental human trials to be carried out

found that blocking activin receptor-like kinase 4/5 (ALK4/5, one of the TGF- receptors) could activate Nrf2 signaling to inhibit erastin-induced ferroptosis in HK-2 cells[131]

Forward-looking analyses suggest that, without intensified prevention, annual new liver cancer cases could rise from ~ 0.87 million (2022) to ~ 1.52 million by 2050, keeping HCC among the leading causes of cancer death worldwide [6]

While cationic polymers like PEI can enhance loading, they introduce well-documented cytotoxicity constraints, forcing an explicit engineering trade-off between delivery potency and biological safety (Shirbaghaee and Bolhassani, 2016)