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According to studies, inflammation induces neurotoxicity and reduces BH4, impairing serotonin, dopamine, and norepinephrine synthesis, which contributes to depression (Zakaria et al., 2022) (Figure 4)

PLoS One 11 (2), e0149991

Welcome to the journal of extracellular vesicles and circulating nucleic acids: a new open-access scientific journal

Later, other authors raised the hypothesis that the carbohydrate intake was not the main concern, but the glycemic index of these (7577)

88 Under physiological copper levels, ATP7A/B are situated in the TGN, where they pump copper into the lumen of the TGN by the copper chaperone ATOX1

Mattioli R, Francioso A, dErme M, Trovato M, Mancini P, Piacentini L, Casale AM, Wessjohann L, Gazzino R, Costantino P, Mosca L (2019) Anti-Inflammatory Activity of A Polyphenolic Extract from Arabidopsis thaliana in In Vitro and In Vivo Models of Alzheimers Disease