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Mechanism of action Postganglionic adrenergic neuron blockers cause presynaptic inhibition of the release of the neurotransmitter from peripheral neurons by agonistic activity on the 2 receptor and depletion of the neurotransmitter through competitive uptake into the neurosecretory vesicles

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This method bypasses the digestive system that can compromise absorption

Research studies used much lower concentrations when testing isolated cells or follicles

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